Serveur d'exploration sur la maladie de Parkinson

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Dystonia and parkinsonism

Identifieur interne : 001A79 ( Main/Exploration ); précédent : 001A78; suivant : 001A80

Dystonia and parkinsonism

Auteurs : Joseph Jankovic [États-Unis] ; Ron Tintner [États-Unis]

Source :

RBID : ISTEX:32103F98B65F548F2909AF852DBE5FC1D679E58B

Abstract

Parkinsonism and dystonia may coexist in a number of neurodegenerative, genetic, toxic, and metabolic disorders and as a result of structural lesions in the basal ganglia. Parkinson's disease (PD) and the ‘Parkinson-plus’ syndromes (PPS) account for the majority of patients with the parkinsonism–dystonia combination. Dystonia, particularly when it involves the foot, may be the presenting sign of PD or PPS and these disorders should be suspected when adults present with isolated foot dystonia. Young age, female gender, and long disease duration are risk factors for PD-related dystonia, but dystonia in patients with PD is usually related to levodopa therapy. The mechanism of dystonia in PD is not well understood and the management is often challenging because levodopa and other dopaminergic agents may either improve or worsen dystonia. Other therapeutic strategies include oral medications (baclofen, anticholinergics and benzodiazepines), local injections of botulinum toxin, intrathecal baclofen, and surgical lesions or high frequency stimulation of the thalamus, globus pallidus, or subthalamus.

Url:
DOI: 10.1016/S1353-8020(01)00025-6


Affiliations:


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Le document en format XML

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